It’s unusual for bladder cancer to run in families, but some types may have a hereditary link. Having one or more immediate family members with bladder cancer doesn’t mean you’ll get this disease. Although genetics may play an important role, other issues that affect your risk like lifestyle choices, are under your control. Smoking triples your risk of developing bladder cancer. Half of all bladder cancer is associated with smoking. Few people with bladder cancer have a rare mutation in the RB1 gene. This gene can cause retinoblastoma, an eye cancer. It may also increase bladder cancer risk. This gene mutation can be inherited. Other hereditary and rare genetic syndromes may increase bladder cancer risk. One is Cowden syndrome, which causes multiple noncancerous growths known as hamartomas. This is more closely linked with increased risk of colon cancer.
Types of bladder cancer include:
Few bladder cancers include more than one type of cell.